LifeMetrics Inc.Publications · Clinical Bioinformatics

LifeMetrics Publications

Technical white papers, methodology notes, and validation reports from the LifeMetrics bioinformatics group. All publications are released for public distribution unless otherwise stated.

White Papers

4 publications

LifeMetrics Inc.Technical White Paper · v1.0
Genomic Analytics · Statistical Imputation
Genomic Imputation Pipeline
Architecture, Quality Control and Analytical Validation
GRCh38 · ShapeIT4 · Beagle 5.5 · High-Coverage 1000 Genomes
Author
Sir Richard M. Taylor, OMS, PgDip, BSc(Hons) PGCE.
Chief Technology Officer & VP of BioInformatics
LifeMetrics Inc.
Document
WP-GIP-001 · Rev. A
Genomic Imputation Technical Specification
Distribution: Public
Date: 15 September 2026
Genomic Analytics · Statistical Imputation
Genomic Imputation Pipeline
A technical white paper describing the GRCh38 architecture, quality controls, phased data products, provenance model, and analytical validation framework.
Author
Sir Richard M. Taylor, OMS, PgDip, BSc(Hons) PGCE.
Document
WP-GIP-001 · Rev. A
Date
15 September 2026
LifeMetrics Inc.Technical White Paper · v1.0
Clinical Genomics · Cancer Predisposition
Whole Genome Clinical Pipeline for Cancer Predisposition
A Technical White Paper
Hereditary Cancer Risk Detection — SNV · Indel · SV · CNV
Author
Sir Richard M. Taylor, OMS, PgDip, BSc(Hons) PGCE.
Chief Technology Officer & VP of BioInformatics
LifeMetrics Inc.
Document
WP-CGP-001 · Rev. A
Clinical-Grade WGS for Cancer Predisposition
Distribution: Public
Date: 14 April 2026
Clinical Genomics · Cancer Predisposition
Whole Genome Clinical Pipeline for Cancer Predisposition
A Technical White Paper describing the end-to-end clinical-grade WGS pipeline for the detection and reporting of inherited cancer predisposition (SNV · Indel · SV · CNV).
Author
Sir Richard M. Taylor, OMS, PgDip, BSc(Hons) PGCE.
Document
WP-CGP-001 · Rev. A
Date
14 April 2026
LifeMetrics Inc.Technical White Paper · v1.1
Clinical Genomics · Pipeline Verification
Validation Tools
A Comprehensive Framework for Clinical Whole Genome Pipeline Verification
Multi-Class Variant Validation Edition — SNV · Indel · SV · CNV-like
Author
Sir Richard M. Taylor, OMS, PgDip, BSc(Hons) PGCE.
Chief Technology Officer & VP of BioInformatics
LifeMetrics Inc.
Document
WP-VAL-001 · Rev. B
Clinical-Grade WGS Validation
Distribution: Public
Date: 29 April 2026
Clinical Genomics · Pipeline Verification
Validation Tools
A Comprehensive Framework for Clinical Whole Genome Pipeline Verification — Multi-Class Variant Validation Edition (SNV · Indel · SV · CNV-like)
Author
Sir Richard M. Taylor, OMS, PgDip, BSc(Hons) PGCE.
Document
WP-VAL-001 · Rev. B
Date
29 April 2026
LifeMetrics Inc.Technical White Paper · v1.0
Clinical Genomics · Distributed Compute Infrastructure
High-Throughput Whole Genome Processing Using a Distributed Apple Silicon Cluster
A Chromosome-Orchestrated, Parallelised Genome Analysis Architecture
Heterogeneous Compute — Thunderbolt 5 Fabric — Sub-2-Minute Turnaround
Author
Sir Richard M. Taylor, OMS, PgDip, BSc(Hons) PGCE.
Chief Technology Officer & VP of BioInformatics
LifeMetrics Inc.
Document
WP-DSC-001 · Rev. A
Distributed Clinical-Grade WGS Compute
Distribution: Public
Date: 2 February 2026
Clinical Genomics · Distributed Compute Infrastructure
High-Throughput Whole Genome Processing Using a Distributed Apple Silicon Cluster
A Chromosome-Orchestrated, Parallelised Genome Analysis Architecture — sub-2 minute clinical WGS turnaround on commodity Apple Silicon nodes interconnected by a Thunderbolt 5 fabric.
Author
Sir Richard M. Taylor, OMS, PgDip, BSc(Hons) PGCE.
Document
WP-DSC-001 · Rev. A
Date
2 February 2026